Tumour necrosis factor blockade in treatment resistant pigmented villonodular synovitis

CONCISE REPORT Tumour necrosis factor a blockade in treatment resistant pigmented villonodular synovitis

Background: Pigmented villonodular synovitis (PVNS) is considered to be a neoplastic-like disorder of the synovium histologically characterised by villonodular hyperplasia, resulting in dense fibrosis and haemosiderin deposition. The pathogenesis of the disease is still unknown. Case report: A patient presented with severe treatment resistant PVNS of the right knee joint. Several conventional t...

Pigmented villonodular synovitis.

Pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVS) is an uncommon, usually monoarticular disorder encountered mainly in adults. A boy and a girl, both 7 years old, were referred because of recurrent knee effusions. Both were medically treated for other rheumatic disorders for five years. PVS was diagnosed by arthroscopy and synovectomy was curative in both cases.

Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment☆

Pigmented villonodular synovitis is a rare proliferative condition of the synovium. Although the condition can present in any joint, the knee is the most commonly affected site. Despite being a benign condition, pigmented villonodular synovitis is often aggressive, with marked extra-articular extension in some cases. Monoarticular involvement occurs in two forms: localized and diffuse. The latt...

Multifocal pigmented villonodular synovitis in a child

INTRODUCTION Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. Multifocal PVNS is very rare, particularly in childhood. We reported a rare case of multifocal PVNS affecting over 20 joints in a child. CLINICAL PROCEDURE A 7-year-old female patient had a 6-month history of multi...